David Zemmour

Ph.D., Immunology, Harvard University , University of Chicago Medicine

Award Year: 2024

Project: Understanding How the Immune Treatments Against Cancer Also Induce Autoimmunity as Side Effects

David Zemmour’s research focuses on directly measuring cellular interactions in human tissues to better understand immune responses. He does this by studying T cells and Regulatory T cells known as Tregs. The immune system consists of millions of cells spread throughout the body, working together to respond to injuries, and Tregs play a unique and crucial role in preventing autoimmune diseases, as was celebrated with the 2025 Nobel Prize in Physiology and Medicine. Dr. Zemmour is currently investigating the role that Tregs play in the onset of immune checkpoint inhibitor (ICI) colitis, which is a significant autoimmunity side effect of cancer treatment. His goal is to uncover the underlying mechanisms of dysfunction of these Tregs during immunotherapy, with the goal of learning how to prevent it in the future.